FightMalaria@Home data now available online
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Ant Chubb
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Message 1680 - Posted: 6 Jan 2015, 16:35:07 UTC

Hi all volunteers,

We have made a results website for easy access to the data we generated using the FM@H BOINC server. The first 400 MMV compounds (MalariaBox) data is available here:
http://chemware.ucd.ie/FiNDaH/Malaria.php

We're still doing the last repeat calculations for the remaining MMV19k and other datasets, the results of which we'll add to this website. We'll also add the TB data to this site, once we've cleaned it up and added orthogonal scoring data.

I had hoped to get the publication out prior to releasing this 'raw' data, but this is taking longer than I'd hoped. Once the paper is submitted I'll add a pre-print to the website also. The scoring functions will then make more sense.

Thanks again for your generous contributions to this project.

We're optimistic that someone, somewhere, will use this data to confirm our findings and provide the world with novel drugs... and new targets for further anti-malarial drug discovery.

ciao,
Ant

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Message 1686 - Posted: 6 Jan 2015, 21:53:26 UTC - in response to Message 1680.

Great! Many thanks!

Wu Shichao
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Message 1687 - Posted: 7 Jan 2015, 2:50:39 UTC - in response to Message 1680.

That's great! And I think your team should let more people know this results website.

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Message 1691 - Posted: 7 Jan 2015, 14:58:49 UTC - in response to Message 1680.

Hi all volunteers,

We have made a results website for easy access to the data we generated using the FM@H BOINC server. The first 400 MMV compounds (MalariaBox) data is available here:
http://chemware.ucd.ie/FiNDaH/Malaria.php

We're still doing the last repeat calculations for the remaining MMV19k and other datasets, the results of which we'll add to this website. We'll also add the TB data to this site, once we've cleaned it up and added orthogonal scoring data.

I had hoped to get the publication out prior to releasing this 'raw' data, but this is taking longer than I'd hoped. Once the paper is submitted I'll add a pre-print to the website also. The scoring functions will then make more sense.

Thanks again for your generous contributions to this project.

We're optimistic that someone, somewhere, will use this data to confirm our findings and provide the world with novel drugs... and new targets for further anti-malarial drug discovery.

ciao,
Ant


Thank you for this update. And, yes this will help. ;)
I will share it via Mail to some "insiders"/researchers.

Wu Shichao
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Message 1695 - Posted: 8 Jan 2015, 0:58:49 UTC - in response to Message 1691.

Well done!

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Message 1696 - Posted: 8 Jan 2015, 1:35:52 UTC

This is why I join projects like this. The work is generated by people with the know-how and given to the general public to render/crunch, after which the results are turned over to the public.

Make sure word in academic circles is spread so the most usage can come from the work completed.

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Message 1918 - Posted: 9 Feb 2015, 14:40:57 UTC - in response to Message 1691.

I will share it via Mail to some "insiders"/researchers.


It is also my concern that too few relevant people will know that this data exists. "I will email some insiders" doesn't sound good enough after all the work the community has done...

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Message 1922 - Posted: 11 Feb 2015, 21:08:30 UTC - in response to Message 1918.

I will share it via Mail to some "insiders"/researchers.


It is also my concern that too few relevant people will know that this data exists. "I will email some insiders" doesn't sound good enough after all the work the community has done...



I guess the most researchers doesn´t know from this research project and there opened result database. I used my contacts to german researchers, like at RKI or BNI [Berhard-Nocht-Institute for tropical medicine]


This could help to find a vaccine.

Ant: https://www.bnitm.de/uploads/media/D_repens_autochthoner-Fall_EuroSurveill_2014.pdf :o

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Message 2290 - Posted: 26 Apr 2015, 8:20:07 UTC

Hi there has been a lot of articles this week thatGSK have been trialling a vaccine that they hope to release in October. Does this affect your work on this ?

Anthony Chubb
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Message 2295 - Posted: 27 Apr 2015, 18:42:58 UTC - in response to Message 2290.

Nope. Vaccines rely on finding good epitopes, injecting these into children, and then watching the immune system react to this non-infectious form of the pathogen.

We are trying to find the proteins that may be the targets for small molecules. If we find a new target, then we could provide the world with a 'first-in-class' drug. This would be very exciting news, as malaria has never seen a drug against this new target, so will not have had a chance to evolve resistance.

I've also had some exciting conversations with Matt Blumberg re validation studies. More on this when it's confirmed.

Ciao,
Ant

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Message 2298 - Posted: 29 Apr 2015, 6:45:44 UTC

Many thanks.

Carlysle J Thomas
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Message 2641 - Posted: 19 Oct 2015, 12:56:31 UTC

I sure hope someone can help me with this. I'm trying to run two "Malaria Apps", Find@Home and MalariaControl.net. No problems at all with MalariaControl.net. But some months ago I stopped receiving work units and nothing seems to happen with FIND@Home. Have re-installed BOINC, and tried to discover any sort of clue on the FIND website, but nada. I have lotsa cycles I'd like to donate (and I have a vested interest since I work in a high-incidence malaria area in Perú).

Can someone give me a clue or a few suggestions or try to talk me through this?

Thanks,
-Jack-
Colorado Springs

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Message 2642 - Posted: 19 Oct 2015, 14:46:46 UTC - in response to Message 2641.

I have had no task download since Oct 17. I even requested several "project_update" actions over the weekend, but no task downloads occurred. Instead, the reply was no tasks available.

I did notice a message on one of the message boards from Oct 16 where the user reported receiving an error message about using the wrong URL for the project (I have not seen this message on my system). So, I detached the project, and requested to add a new project. I am using BOINCTUI, so I picked the FiND@Home from the list it presented, told it I was an existing user, entered my username and password, and suddenly I was downloading a new set of tasks.

What I would like to learn from Find@Home is if this is a routing occurrence. Is detaching and adding the project periodically necessary due to some reconfiguration they implement with their servers?

Next time, I won't spend 3 days trying to execute a project_update. I'll just remove and re-add the project.

This is not a good approach to keeping the project running.
Most concerning is that there were on warnings about this problem from project administrators.

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Message 2643 - Posted: 19 Oct 2015, 14:48:42 UTC

Hi Jack,

Thanks for your interest in this project. The short answer is that demand for work seems to outstrip supply. There are probably Boinc tweaks you can make to check the server more frequently for work, but that's not my forte. I just hope for the best, and in the mean time my computers continue to chew through work for MalariaControl and a couple other Boinc projects I've selected. But that doesn't always work. I did 1 WU yesterday.

Perhaps someone with more expertise in Boinc can help you get more FIND work.

mikey
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Message 2644 - Posted: 19 Oct 2015, 15:05:26 UTC - in response to Message 2642.
Last modified: 19 Oct 2015, 15:06:40 UTC

I have had no task download since Oct 17. I even requested several "project_update" actions over the weekend, but no task downloads occurred. Instead, the reply was no tasks available.

I did notice a message on one of the message boards from Oct 16 where the user reported receiving an error message about using the wrong URL for the project (I have not seen this message on my system). So, I detached the project, and requested to add a new project. I am using BOINCTUI, so I picked the FiND@Home from the list it presented, told it I was an existing user, entered my username and password, and suddenly I was downloading a new set of tasks.

What I would like to learn from Find@Home is if this is a routing occurrence. Is detaching and adding the project periodically necessary due to some reconfiguration they implement with their servers?

Next time, I won't spend 3 days trying to execute a project_update. I'll just remove and re-add the project.

This is not a good approach to keeping the project running.
Most concerning is that there were on warnings about this problem from project administrators.


The problem is that there are more users than units available, so they run out of units here sometimes. Then the work generator works hard and there are units again, it's essentially the same at every project. Some projects can drop hundreds of thousands of workunits at once into the queue, other tend to drop fewer at a time.

mikey
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Message 2645 - Posted: 19 Oct 2015, 15:10:13 UTC - in response to Message 2641.

I sure hope someone can help me with this. I'm trying to run two "Malaria Apps", Find@Home and MalariaControl.net. No problems at all with MalariaControl.net. But some months ago I stopped receiving work units and nothing seems to happen with FIND@Home. Have re-installed BOINC, and tried to discover any sort of clue on the FIND website, but nada. I have lotsa cycles I'd like to donate (and I have a vested interest since I work in a high-incidence malaria area in Perú).

Can someone give me a clue or a few suggestions or try to talk me through this?

Thanks,
-Jack-
Colorado Springs


This project just has more users than workunits right now, MalariaControl generates units based on the previous batches results, so although they tend to also be small in number they tend to generate new units pretty regularly when they are in full operation. MalariaControl DOES have times when they have little to no units available, it just part of the way they run their project.

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