Exciting news from the FM@H project - first in vitro validation comes up with hits!
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Message boards : News : Exciting news from the FM@H project - first in vitro validation comes up with hits!

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Ant Chubb
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Message 654 - Posted: 16 May 2013, 9:41:49 UTC

Dear all,
We've had our first major success from the FightMalaria@Home project. After analyzing the data generated in the first phase (docking all the 400 MalariaBox compounds against all models), we have ranked lists of potential inhibitors for each receptor. But are these real? This is the kind of question that keeps us up at night.
Now we can rest easy - we've tested the top 20 hits using a model of the Plasmodial form of HDAC (histone deacetylase) in a laboratory (Dr Marian Brennan, RCSI, Dublin), and found THREE new inhibitors! So that's just one of the 1,500 receptors that we're docking, using only the best docking results (i.e. only the 20 best ligands).
It's a fantastic result, giving us hope that there are other gems waiting to be found in the data that you've generated on your home PCs!
Well done everyone!!!!!
ps: We're in the process of writing up a manuscript for publication in an open-access journal, so you'll be able to read about all the details, and download all the data generated from FM@H, once we've survived the peer review process.

Thyme Lawn
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Message 655 - Posted: 16 May 2013, 13:23:05 UTC - in response to Message 654.

Excellent news Ant! Hope the peer review goes smoothly.
"The ultimate test of a moral society is the kind of world that it leaves to its children." - Dietrich Bonhoeffer

Vyhnal Zdenek
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Message 656 - Posted: 16 May 2013, 17:12:54 UTC

Great news.
Congratulations and good luck - continue...

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Message 657 - Posted: 17 May 2013, 6:17:36 UTC

C'est une bonne nouvelle ; continuons !
Good news ; continue !

Jack Lightholder
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Message 658 - Posted: 17 May 2013, 17:40:39 UTC

Great to hear, congratulations! Keep us posted on future work/developments.

John C MacAlister
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Message 659 - Posted: 18 May 2013, 16:35:44 UTC
Last modified: 18 May 2013, 16:37:08 UTC

Hi, Ant:

Congratulations and all the best with the next steps. Thank you for the update. I am pleased to see that our volunteer crunching is helping with useful work.

Let's all keep running.


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Message 660 - Posted: 20 May 2013, 15:48:06 UTC

Hello Ant,

thanks for sharing these in vitro validation results with us. This is exciting, indeed!! Congratulations to the project team and everyone involved.


Message boards : News : Exciting news from the FM@H project - first in vitro validation comes up with hits!

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